Epistem’s specialist contract research services provide valuable support to drug discovery and development pipelines. Epistem’s experienced and skilled technical team are dedicated to working with you to provide custom protocols and a personalised service of the highest standard. Epistem Pharmacogenomics services are the ideal complement to Epistem’s contract research models. We have worked with over 200 pharmaceutical and biotechnology companies providing biomarker and personalised medicine analyses at both preclinical and clinical stages. We specialise in advancing drug development programs for oncology, inflammatory and GI-Toxicity indications through our innovative plucked hair analysis and laser capture microdissection techniques as well as offering GCLP accredited laboratory gene expression and DNA genotyping services. Epistem’s proprietary RNA-amp technology facilitates the analysis of gene expression from very low amounts of starting material such as circulating tumour cells and liquid biopsies. We have engaged with pharmaceutical companies with contractual fee for service models as well as collaborative partnership programs in biomarker and target discovery and our high level of expertise and customer focus has led to an enviable track record and impressive repeat business ratio.


Target validation, novel therapeutic agent efficacy in specialised tumour models and GCLP compliant biomarker studies


Living Skin Equivalents, organ cultures and full thickness skin graft models using defined donor skin types

GI Toxicity and Mucositis

Identification of the causes of changes to epithelial regulation; extensively characterised mucositis models

Wound Healing

In vitro assays and in vivo incisional and excisional models of wounding


Evaluation of medical countermeasures for the acute and delayed effects of radiation exposure

Hair Biomarker Platform

Pre-clinical evaluations and clinical studies with GCLP analysis using plucked hairs as a surrogate tissue


Extensively characterised in vivo IBD and CIA models and mechanistic pathways

Analytical Services

Comprehensive range of endpoint analyses including IHC, imaging, FACS, multiplex and gene expression

Assessing Limited Quantities of RNA

GCLP accredited laboratory generating biomarker, target discovery and personalised medicine data from very limited quantities of RNA using our proprietary amplification technique RNA-Amp™.

Gene Expression Analysis

Global and focused GCLP accredited mRNA and miRNA gene expression profiling and data analysis services.

Laser Capture Microdissection

Isolate specific cell populations from tissue sections using Laser Capture Microdissection (LCM) and subsequent gene expression or DNA genotyping analysis

DNA Genotyping Analysis

We specialise in developing and validating genotyping assays and analysis of clinical samples