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Cancer Stem Cell Assays
Assessing drug efficacy on tumour progentitors
Normal proliferating tissues are maintained by a stem cell population. Growing evidence suggests that tumours are derived from, and maintained by, a similar self-renewing subpopulation of undifferentiated cells: cancer stem cells. Studies of the behaviour of such cells are leading to new diagnostics and targeted cancer stem cell therapeutics.
Working in collaboration with Dr Robert Clarke (Paterson Institute For Cancer Research), and drawing upon our own stem cell experience, Epistem is developing cancer stem cell assays for more targeted drug screening.
Readouts | .jpg "Epistem - Holoclone (cancer stem-like cells) in culture") Image: Holoclone (cancer stem-like cells) in culture test |
- The Tumour Sphere assay measures the effect of an agent on the ability to form stem cell colonies (i.e a measure of direct effects upon stem cells).
- The Adherent Clonal assay measures the differential effect of agents on stem cell-like cells compared to proliferating and differentiated cells in the same assay