Brochures

All Disciplines

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Analytical Services

Analytical Services

Epistem provides a suite of analytical services which can be utilised as an integrated component of an in-house study package or as a stand-alone service.

GI Toxicity and Mucositis

Mucositis
Mucositis Drug Discovery Platform

Epistem has world recognised intestinal and oral mucositis expertise, providing industry standard models predictive of clinical outcome.

Epithelial Toxicity
Specialised Analysis of Epithelial Toxicity

Epistem provides specialist epithelial tissue and stem cell analysis to investigate the aetiology, mechanism and prevention of epithelial toxicity.

Histology and IHC Services

Histology
Histology and Immunohistochemistry Services

Epistem provides a tailored histology and immunohistochemistry service to assist with the validation of novel therapeutic targets, either as part of an integrated package or as a stand-alone service. The service is delivered by experienced histologists

Inflammation

Inflammation
In Vitro and In Vivo Models for Inflammatory Disease

Epistem’s inflammation experts provide a range of specialised preclinical models to support target validation and drug development for inflammatory diseases.

Inflammatory Bowel Disease
Preclinical Models for Crohn’s Disease
and Ulcerative Colitis

High quality preclinical data from a range of in vivo IBD models and target validation studies to aid the development of new anti-inflammatory therapies.

Oncology

Cancer Stem Cells

Epistem offers tumour sphere assays as part of a comprehensive preclinical oncology programme, from initial assessment of target gene or protein expression to evaluation of cancer stem cell targeting efficacy in vitro.

Angiogenesis

In Vitro and In Vivo Human Angiogenesis Assays

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Leukemia
In Vivo Orthotopic Models of Patient-Derived (PDX) and Cell Line Based Leukemia

Epistem provides clinically relevant in vivo models of leukemia using both patient-derived material and established cell line models. Luciferase imaging enables early detection of leukemia, allowing for an extended treatment window and longitudinal mo

Orthotopic and Metastatic Cancer
In Vivo Orthotopic Models
for More Accurate Representation of Clinical Disease

Epistem provides clinically relevant orthotopic in vivo models of solid and metastatic tumors, using highly sensitive state-of-the-art optical imaging with luc+ cell lines, enabling real time visualization of therapeutic outcomes.

Pharmacogenomics

RNA-Amp™ Kits
Kits for Highly Sensitive and Reproducible Gene Expression Analysis

Epistem RNA-Amp™ amplification kits are extremely sensitive and user friendly. Our kits use a proprietary combination of components to amplify cDNA prepared from small amounts of tissue and RNA.

DNA Genotyping

Epistem provides laboratory GCLP (microarray and qPCR) and point of care (Genedrive®) ISO 13485 accredited DNA genotyping services.

Gene Expression
Global and Focused mRNA and miRNA
Profiling Services

Epistem provides global (microarray) and focused (qPCR) GCLP accredited mRNA and miRNA gene expression profiling services. Expression profiles can be generated from pg-μg levels of RNA permitting analysis of small starting materials

Transcriptome Analysis
Assessing Limited Quantities of RNA

Epistem’s proprietary amplification technique, RNA-Amp™, allows robust gene expression information to be derived from as little as a single cell input.

Laser Capture Microdissection
Gene Expression Analysis of Isolated Cell Populations

Epistem offers Laser Capture Microdissection (LCM) services and subsequent gene expression and DNA genotype analysis. This technique is an ideal method for obtaining molecular analysis of specific cell populations. Following the isolation of cells of i

Plucked Hair Biomarker Platform

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Plucked Hair Biomarker Analysis
Reproducible Gene Expression Profiles from Plucked Hair

Plucked hair is an attractive non-invasive surrogate tissue to aid drug development programs, particularly with respect to phamacodynamic biomarker discovery and clinical applications. With low intra- and inter-donor variation key to successful utility

Plucked Hair Biomarker Platform
Gene and Protein Expression in Single Scalp Hairs

Epistem provides a unique plucked hair biomarker platform to drug development companies targeting intracellular signalling pathways in oncology and other therapeutic areas. Plucked hair analysis offers a simple to apply and minimally invasive techniqu

Skin

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Wound Healing

In Vitro Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.

In Vivo Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.