Epistem has developed an acute, collagen-induced arthritis model. This model exhibits many disease parameters representative of those observed in patients with rheumatoid arthritis.
Collagen-Induced Arthritis Model Description
Arthritis is established by a single injection of type II collagen. This leads to joint swelling and deformity. Disease onset is typically observed 3 weeks post immunisation. The effect of novel therapeutic agent administration on the penetrance and severity of disease can be quantified.
- Clinical score
- Joint swelling
- Histology and immunohistochemistry
- Anti-collagen IgG responses
- FACS analysis
- Multiplex analysis of cytokines
- Gene expression