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In vitro Skin Models
Epistem provides a range of in vitro models that provide an alternative to in vivo human studies.
Human Skin Equivalent
Human Skin Organ Culture (Skin Explant Assay)
UV Photodamage Assay
Skin Stem Cell Assays
A range of in vitro assay systems, including the anchorage-independent growth of cell microspheres and the identification of Hoechst-dye excluding side populations. This provides valuable information on the ability of an agent to expand skin stem populations.
Epistem isolates and maintains primary cultures of human epidermal keratinocytes, melanocytes and dermal fibroblasts for test agent screening.
Skin Toxicity Assay
Epistem's Human Skin Equivalent is also used to assess the potential toxicity of agents to human skin. Dose ranging toxicity experiments are performed and a range of techniques are used to determine potential toxic effects (WST-1 assay, IL-2α ELISA, IHC and gene expression analysis).