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Wound Healing

Improved healing of large wounds via the reprogramming of wound-resident mesenchymal cells into epithelial cells

The authors of this paper demonstrated that mesenchymal cells within a large wound could be converted into keratinocytes in vivo via the transduction of four genes. This improved re-epithelialization of wounds through generation of new epithelial tissue that showed normal morphology/characteristics and eventually connected to host skin. The paper provides proof of principle for a new wound healing treatment particularly useful for large wounds that normally require skin grafts.

Memory of EpSC in Wound Healing

Summary of a study investigating how skin inflammation effects EpSCs to allow them to speed up barrier restoration following subsequent tissue damage.

A new opportunity to reduce scarring by converting myofibroblasts to adipose cells?

Epistem has validated in vivo excisional and incisional, human skin engraft, diabetic and LPS-induced inflammation wound healing models. In vitro wound healing assays are also available to assess cell proliferation/migration, wound closure and angiogenesis.

FDA approval for new diabetic wound dressing.

Epistem validated in vivo diabetic wound healing model showing delayed wound healing (wound closure and re-epithelisation) and a decreased inflammatory response.