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Target Validation

Cancer stem cell sphere formation

Cancer Stem Cell Assay

Angiogenesis control tubule growth

Angiogenesis

A transverse section through human skin, 6 weeks post s.c. engraftment

Subcutaneous Xenografts

Angiogenesis inhibited tubule growth

Orthotopic Models

Luminal view of a small intestine adenoma

Min+/- Model

BrdU staining of normal tongue

Therapy Side Effects