Epistem Limited

disease & therapeutic research models

Inflammatory Bowel Disease

GI Toxicity and Mucositis

Immune Cell Assays

Rheumatoid Arthritis

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Gene Expression Analysis

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Spotlight On...

Lgr5+ telocytes are a signalling source at the intestinal villus tip
A recent study utilising spatially-resolved transcriptomics and laser capture microdissection has discovered that Lgr5+ telocytes act as a signalling…
CD47 is a negative regulator of intestinal epithelial cell self-renewal …
Scientists have demonstrated that epithelial cell CD47 expression in the colon is strongly induced in patients with ulcerative colitis and Crohn's…
Location-specific cell identity rather than exposure to GI microbiota defines …
A recent study established a biobank of human and murine GI organoids from tissue-resident stem cells and analysed gene expression to discover that…
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway …
A recent study has used single-cell RNA-seq data to analyse human, non-human primate and mouse barrier tissue to identify putative SARS-CoV-2…
Ileal apoptosis and microbiota mediate colon cancer treatment efficacy
A recent study sheds further light on the interdependent relationship between the intestinal epithelium, the intestinal microbiome and host immunity,…

Announcements

ANNOUNCING:
RECRUITING: SENIOR OR PRINCIPAL SCIENTIST - FIBROSIS MODELS
Epistem are on the lookout for an individual with a strong background in fibrotic remodeling with industry experience or 5 years post-doc
NEWS: Epistem licence Hubrecht Organoid Technology to expand preclinical toxicology service portfolio
2019-07-15
Epistem Limited has announced the expansion of its in vitro model portfolio by the completion of an agreement with Hubrecht Organoid Technology (HUB)…
NEWS: 10 Years GCLP Accreditation at Epistem
2019-01-11
We are pleased to announce the successful GCLP re-accreditation of our laboratories.

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