Established in 2000 by Prof. Chris Potten and Dr. Cath Booth, Epistem's scientific foundation is based on several decades of ground-breaking stem cell research by Prof. Potten. Based at the Paterson Institute for Cancer Research at the Christie Hospital and the University of Manchester, UK, Prof. Potten identified and characterised the location and behaviour of stem cells in the intestine, skin, hair follicle and breast.
To support this revolutionary research, the team developed powerful models to understand the controls of epithelial cell turnover and methods to quantify tissue damage, regeneration and metaplasia. As a result of increasing demand from pharmaceutical and biotechnology companies for access to these models, Prof. Potten and Dr. Booth formed Epistem.
In 2001, Epistem moved into the current purpose-built facilities featuring specialist in vivo and general 'wet labs' as well as dedicated cell culture, histology and microscope suites. Epistem has continued to expand in these state-of-the-art facilities, developing the portfolio of services into further therapeutic areas and integrating additional academic and industry experts into the team.
Epistem continues to develop innovative and clinically relevant assays and models and is frequently invited to present at international meetings. Maintaining close links with drug development companies, clinicians and academics in the field, Epistem remains a leader in the field of preclinical testing.