Epistem's clinically relevant ex vivo skin organ culture model features a genuine dermis. Cultured skin biopsies are used to investigate the effect of novel therapeutic agents, providing data which can easily be translated to human skin. Epistem can source skin samples according to requirements to ensure the model is representative of a specified skin type, including human hairy skin, which can be used to assess the effect of therapeutic agents on hair growth.
Epistem's team have many years of experience with skin organ cultures, ensuring reproducible and high quality data which can be used for claims and patent support. This service is supported by Epistem's fully GCLP accredited histology and immunohistochemistry service.
Skin Organ Culture Description
A biopsy of human skin is maintained in culture. Novel therapeutic agents can be applied topically and systemically throughout a testing window of 7-10 days.
- Histometric analysis
- Cell turnover rates
- WST-1 assay for cytotoxicity screening
- UV damage marker quantification
- Gene expression including anti-ageing and anti-oxidant pathways
- Protein expression
Further readouts available on request.