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brochure listing

Analytical Services

Gene Expression Analysis

RNA-Amp
Kits for Highly Sensitive and Reproducible Gene Expression Analysis

Epistem RNA-Amp

DNA Genotyping

DNA Genotyping

Epistem provides laboratory GCLP (microarray and qPCR) and point of care (Genedrive

GI Toxicity and Mucositis

Epithelial Toxicity
Specialised Analysis of Epithelial Toxicity

Epistem provides specialist epithelial tissue and stem cell analysis to investigate the aetiology, mechanism and prevention of epithelial toxicity.

Histology and IHC Services

Inflammatory Bowel Disease

Inflammatory Bowel Disease
Preclinical Models for Crohn

High quality preclinical data from a range of in vivo IBD models and target validation studies to aid the development of new anti-inflammatory therapies.

Laser Capture Microdissection

Mucositis

Epithelial Toxicity
Specialised Analysis of Epithelial Toxicity

Epistem provides specialist epithelial tissue and stem cell analysis to investigate the aetiology, mechanism and prevention of epithelial toxicity.

Oncology

Angiogenesis
In Vitro and In Vivo Human Angiogenesis Assays

In Vitro and In Vivo Human Angiogenesis Assays

Leukemia
In Vivo Orthotopic Models of Patient-Derived (PDX) and Cell Line Based Leukemia

Epistem provides clinically relevant in vivo models of leukemia using both patient-derived material and established cell line models. Luciferase imaging enables early detection of leukemia, allowing for an extended treatment window and longitudinal mo

Plucked Hair Analysis

Skin Diseases

Wound Healing

In Vitro Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.

In Vivo Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.

Organoids

poster listing

Oncology

Animal Models of Prostate Cancer
Poster presented at the AACR 2019

We have developed a reproducible, well growing and robust subcutaneous model of LNCaP with an effective response to both conventional standard of care (SOC) chemotherapy such as docetaxel and the non-steroidal androgen receptor inhibitor bicalutamide (Casodex).

Plucked Hair Analysis

Plucked Anagen Scalp Hair
A comparison between different analytical techniques

Ex vivo plucked hair assessment generated a dose-dependent and biologically relevant transcriptional signature following exposure to BEZ235, and substantiate that plucked anagen scalp hair is an ideal non-invasive surrogate tissue to obtain drug-induced pharmacodynamic biomarker and target engagement information from oncology patients.