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brochure listing

Analytical Services

Analytical Services

Epistem provides a suite of analytical services which can be utilised as an integrated component of an in-house study package or as a stand-alone service.

Gene Expression Analysis

Gene Expression
Global and Focused mRNA and miRNA Profiling Services

Epistem provides global (microarray) and focused (qPCR) GCLP accredited mRNA and miRNA gene expression profiling services. Expression profiles can be generated from pg-μg levels of RNA permitting analysis of small starting materials

Transcriptome Analysis
Assessing Limited Quantities of RNA

Epistem’s proprietary amplification technique, RNA-Amp™, allows robust gene expression information to be derived from as little as a single cell input.

RNA-Amp™ Kits
Kits for Highly Sensitive and Reproducible Gene Expression Analysis

Epistem RNA-Amp™ amplification kits are extremely sensitive and user friendly. Our kits use a proprietary combination of components to amplify cDNA prepared from small amounts of tissue and RNA.

DNA Genotyping

DNA Genotyping

Epistem provides laboratory GCLP (microarray and qPCR) and point of care (Genedrive®) ISO 13485 accredited DNA genotyping services.

GI Toxicity and Mucositis

Mucositis
Mucositis Drug Discovery Platform

Epistem has world recognised intestinal and oral mucositis expertise, providing industry standard models predictive of clinical outcome.

Epithelial Toxicity
Specialised Analysis of Epithelial Toxicity

Epistem provides specialist epithelial tissue and stem cell analysis to investigate the aetiology, mechanism and prevention of epithelial toxicity.

Histology and IHC Services

Histology
Histology and Immunohistochemistry Services

Epistem provides a tailored histology and immunohistochemistry service to assist with the validation of novel therapeutic targets, either as part of an integrated package or as a stand-alone service. The service is delivered by experienced histologists

Inflammatory Bowel Disease

Inflammation
In Vitro and In Vivo Models for Inflammatory Disease

Epistem’s inflammation experts provide a range of specialised preclinical models to support target validation and drug development for inflammatory diseases.

Inflammatory Bowel Disease
Preclinical Models for Crohn’s Disease and Ulcerative Colitis

High quality preclinical data from a range of in vivo IBD models and target validation studies to aid the development of new anti-inflammatory therapies.

Laser Capture Microdissection

Laser Capture Microdissection
Gene Expression Analysis of Isolated Cell Populations

Epistem offers Laser Capture Microdissection (LCM) services and subsequent gene expression and DNA genotype analysis. This technique is an ideal method for obtaining molecular analysis of specific cell populations. Following the isolation of cells of i

Mucositis

Mucositis
Mucositis Drug Discovery Platform

Epistem has world recognised intestinal and oral mucositis expertise, providing industry standard models predictive of clinical outcome.

Epithelial Toxicity
Specialised Analysis of Epithelial Toxicity

Epistem provides specialist epithelial tissue and stem cell analysis to investigate the aetiology, mechanism and prevention of epithelial toxicity.

Oncology

Angiogenesis
In Vitro and In Vivo Human Angiogenesis Assays

In Vitro and In Vivo Human Angiogenesis Assays

Cancer Stem Cells
In Vitro Assay to Assess Cancer Stem Cell Targeting Agents

Epistem offers tumour sphere assays as part of a comprehensive preclinical oncology programme, from initial assessment of target gene or protein expression to evaluation of cancer stem cell targeting efficacy in vitro.

Leukemia
In Vivo Orthotopic Models of Patient-Derived (PDX) and Cell Line Based Leukemia

Epistem provides clinically relevant in vivo models of leukemia using both patient-derived material and established cell line models. Luciferase imaging enables early detection of leukemia, allowing for an extended treatment window and longitudinal mo

Orthotopic and Metastatic Cancer
In Vivo Orthotopic Models for More Accurate Representation of Clinical Disease

Epistem provides clinically relevant orthotopic in vivo models of solid and metastatic tumors, using highly sensitive state-of-the-art optical imaging with luc+ cell lines, enabling real time visualization of therapeutic outcomes.

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Plucked Hair Analysis

Plucked Hair Biomarker Platform
Gene and Protein Expression in Single Scalp Hairs

Epistem provides a unique plucked hair biomarker platform to drug development companies targeting intracellular signalling pathways in oncology and other therapeutic areas. Plucked hair analysis offers a simple to apply and minimally invasive techniqu

Plucked Hair Biomarker Analysis
Reproducible Gene Expression Profiles from Plucked Hair

Plucked hair is an attractive non-invasive surrogate tissue to aid drug development programs, particularly with respect to phamacodynamic biomarker discovery and clinical applications. With low intra- and inter-donor variation key to successful utility

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Skin Diseases

In Vitro Human Skin Models
3-D Human Skin Models and Monolayer Culture

Epistem provides a range of specialist in vitro models of human skin to cosmetic, personal care and pharmaceutical companies for claims and patent support, biomarker proof of concept and efficacy testing.

Xenografting
Epithelial Tumour Xenograft Services

Epistem provides specialist subcutaneous xenografting services covering a comprehensive range of in vivo epithelial tumour models. Specialist radiation and chemotherapy combination models, and complementary assessment of target and biomarker ...

Wound Healing

In Vitro Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.

In Vivo Wound Healing
Preclinical Models of Wound Healing

Epistem provides a range of in vitro and in vivo models to assess the complex processes involved in wound healing and to determine the effect of agents on healing rate.

poster listing

Oncology

Animal Models of Prostate Cancer
Poster presented at the AACR 2019

We have developed a reproducible, well growing and robust subcutaneous model of LNCaP with an effective response to both conventional standard of care (SOC) chemotherapy such as docetaxel and the non-steroidal androgen receptor inhibitor bicalutamide (Casodex).

Plucked Hair Analysis

Plucked Anagen Scalp Hair
A comparison between different analytical techniques

Ex vivo plucked hair assessment generated a dose-dependent and biologically relevant transcriptional signature following exposure to BEZ235, and substantiate that plucked anagen scalp hair is an ideal non-invasive surrogate tissue to obtain drug-induced pharmacodynamic biomarker and target engagement information from oncology patients.