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Epistem provides a unique plucked hair biomarker platform
to drug development companies targeting intracellular
signalling pathways in oncology and other therapeutic areas.
Plucked hair analysis offers a simple to apply and minimally
Plucked hair is an attractive non-invasive surrogate tissue to aid
drug development programs, particularly with respect to
phamacodynamic biomarker discovery and clinical applications.
With low intra- and inter-donor variation key to successful utility
Epistem provides specialist subcutaneous xenografting
services covering a comprehensive range of in vivo epithelial
Specialist radiation and chemotherapy combination models,
and complementary assessment of target and biomarker
Ex vivo plucked hair assessment generated a dose-dependent and biologically relevant transcriptional signature following exposure to BEZ235, and substantiate that plucked anagen scalp hair is an ideal non-invasive surrogate tissue to obtain drug-induced pharmacodynamic biomarker and target engagement information from oncology patients.
Gene Expression Analysis
GI Toxicity and Mucositis
Histology and IHC Services
Inflammatory Bowel Disease
Laser Capture Microdissection
Plucked Hair Analysis
All global categories
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Accelerating Drug Development with Innovative Services
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