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Epistem provides a unique plucked hair biomarker platform
to drug development companies targeting intracellular
signalling pathways in oncology and other therapeutic areas.
Plucked hair analysis offers a simple to apply and minimally
Plucked hair is an attractive non-invasive surrogate tissue to aid
drug development programs, particularly with respect to
phamacodynamic biomarker discovery and clinical applications.
With low intra- and inter-donor variation key to successful utility
Epistem provides specialist subcutaneous xenografting
services covering a comprehensive range of in vivo epithelial
Specialist radiation and chemotherapy combination models,
and complementary assessment of target and biomarker
Ex vivo plucked hair assessment generated a dose-dependent and biologically relevant transcriptional signature following exposure to BEZ235, and substantiate that plucked anagen scalp hair is an ideal non-invasive surrogate tissue to obtain drug-induced pharmacodynamic biomarker and target engagement information from oncology patients.
Gene Expression Analysis
GI Toxicity and Mucositis
Histology and IHC Services
Inflammatory Bowel Disease
Laser Capture Microdissection
Plucked Hair Analysis
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Accelerating Drug Development with Innovative Services
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