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poster listing

Animal Models of Prostate Cancer

Animal Models of Prostate Cancer
Poster presented at the AACR 2019

We have developed a reproducible, well growing and robust subcutaneous model of LNCaP with an effective response to both conventional standard of care (SOC) chemotherapy such as docetaxel and the non-steroidal androgen receptor inhibitor bicalutamide (Casodex).

Plucked Scalp Hair to Monitor Drug Response

Plucked Anagen Scalp Hair
A comparison between different analytical techniques

Ex vivo plucked hair assessment generated a dose-dependent and biologically relevant transcriptional signature following exposure to BEZ235, and substantiate that plucked anagen scalp hair is an ideal non-invasive surrogate tissue to obtain drug-induced pharmacodynamic biomarker and target engagement information from oncology patients.