Correlation between Gastric Cancer Transcriptome and Histotype Demonstrates Prognostic Potential
In this study, researchers identified biomarkers for intestinal and diffuse gastric cancer which could be targets for therapeutics.
Integrative RNA-Seq and ChIP-Seq Analysis of Human Lung Cancer Cells Isolated by Laser Microdissection
A study looking at the development of a workflow for integrative RNA-sequencing (RNA-Seq) and chromatin immunoprecipitation sequencing (ChIP-Seq) using laser capture microdissected clinical samples of LUAD and LUSC.
Heterogeneous cellular response to ionising radiation revealed by single cell transcriptome sequencing
In this study, the authors used single-cell transcriptomic analysis to determine the effects of ionising radiation in a breast cancer cell line. Despite cell lines being relatively homogenous populations of cells, the authors demonstrate subpopulations of cells that may be resistant to IR treatment.
Tumour Infiltrating Effector Memory Antigen-Specific CD8+ T‑Cells Predict Response to Immune Checkpoint Therapy
An oncology study to determine if infiltrating T-cells could be used as a biomarker for response to immune checkpoint inhibitor therapies.
The serotonin reuptake transporter is reduced in the epithelium of active Crohn’s disease and ulcerative colitis
Our team recently came across an IBD study which demonstrated for the first time that the serotonin reuptake transporter protein is downregulated in inflamed intestinal tissue.
Targeted Next-Generation Sequencing Analysis for Recurrence in Early-Stage Lung Adenocarcinoma
To identify prognostic biomarkers for recurrence of lung adenocarcinoma, and improve treatment stratification and prediction of outcome, a recent study used targeted sequencing of early-stage lung adenocarcinomas with a panel of 170 cancer-related genes and 37 fusion genes.
Biomarker function of HMGA2 in ultraviolet-induced skin cancer development
A recent study discovered that HMGA2 is highly expressed in human cutaneous squamous cell carcinoma (SCC) cell lines and primary SCC tumours, but not in adjacent normal skin.
Ileal apoptosis and microbiota mediate colon cancer treatment efficacy
A recent study sheds further light on the interdependent relationship between the intestinal epithelium, the intestinal microbiome and host immunity, and their combined influence on homeostasis and disease.
Probiotic Bacillus subtilis protects against α-synuclein aggregation in C.elegans
A new study looking at B.subtilis in C.elegans could open the possibilities of diet-based intervention and the development of protective bacterial metabolites to combat Parkinson's disease.
ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumour activity following irradiation
Authors of a recent study have shown that the ATR kinase inhibitor combined with local tumour radiation generated a durable CD8+ T cell-dependent anti-tumour response.