Fibrosis and COVID-19

Researchers have identified a unique COVID-19 signature in the lung, the mechanisms of which are contributors towards fibrosis.

ACE2 contributes to the maintenance of mouse epithelial barrier function

A recent COVID-19 study has utilised organoids to look into the effects of deleting ACE2, the protein which the virus uses to enter the cell.

SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

A recent study has used single-cell RNA-seq data to analyse human, non-human primate and mouse barrier tissue to identify putative SARS-CoV-2 targets.

Immune cell proļ¬ling of COVID-19 patients in the recovery stage by single-cell sequencing

Authors of a recent COVID-19 study have applied single cell sequencing to characterise the immune cell repertoire and gene expression changes in recovering patients.