Spotlight on Lung Fibrosis: Activation of JUN in fibroblasts promotes pro-fibrotic programme and modulates protective immunity.

Pulmonary fibrosis is a progressive, typically fatal lung disease with few curative treatments. This study investigated the specific immune mechanisms that promote fibrosis and suggested a therapeutic approach that could be used alongside conventional anti-fibrotic drugs.

Spotlight on Liver Fibrosis Treatment with mRNA-based Drugs

mRNA-based therapeutics have been boosted by the success of Covid-19 vaccines but have not been evaluated for many other studies including liver fibrosis. In this study the authors evaluate HNF4A expression as a potential treatment for liver fibrosis and cirrhosis.

Spotlight on Kidney Fibrosis

A recent Nature paper used single cell transcriptomic analysis to investigate scar-forming cells and therapeutic gene targets in kidney fibrosis

Spotlight on Liver Zonation and Immune Defence

A recent paper demonstrated that liver sinusoidal endothelial cells organize immune cells into anatomical immune zones by forming chemokine gradients

Fibrosis and COVID-19

Researchers have identified a unique COVID-19 signature in the lung, the mechanisms of which are contributors towards fibrosis.