The delayed effects of acute radiation exposure within the mouse intestine
Partial-body irradiation (PBI) models with minimal (2.5% or 5%) Bone Marrow (BM) sparing results in Acute GI Damage (GI-ARS). However, it enables longer-term survival against radiation levels that would normally be lethal due to BM Toxicity enabling us to study the long-term effects of exposure.
The relationship between epithelial cell fate, microbiota composition and inflammation in the intestine
How perturbation of the homeostatic mechanisms governing epithelial cell fate in the intestine influence the gut microbiota and the susceptibility to colitis. The influence of structural proteins on key signalling pathways and their downstream transcriptional machinery are discussed.
A new paper demonstrates that BMP limits Lgr5+ stem cell number in intestinal epithelial cells
The paper demonstrates that BMP acts via Smad to transcriptionally repress a range of stem cell associated genes, including Lgr5, and that this is independent of the Wnt//β‑catenin signalling pathway.
New paper demonstrating the microbiota impact on cell proliferation via microRNA expression changes in intestinal epithelial stem cells
Intestinal flora are known to impact the immune system and metabolism, with chronic exposures to certain flora linked to conditions such as inflammatory bowel disease and fibrosis. Breeches of the epithelial barrier and systemic infection can lead to more acute problems such as sepsis.
Citrulline as a Biomarker of GI Toxicity
Citrulline is produced by small bowel enterocytes, with circulating citrulline levels correlating with enterocyte mass. Changes in enterocyte number (or in some cases function) are therefore reflected in plasma levels. As a result, citrulline levels may be a biomarker for various GI syndromes