Heterogeneous cellular response to ionising radiation revealed by single cell transcriptome sequencing
In this study, the authors used single-cell transcriptomic analysis to determine the effects of ionising radiation in a breast cancer cell line. Despite cell lines being relatively homogenous populations of cells, the authors demonstrate subpopulations of cells that may be resistant to IR treatment.
Targeting Phosphatidylserine Enhances the Anti-tumour Response to Tumour-directed Radiation Therapy in a Preclinical Model of Melanoma
In this study, researchers detected phosphatidylserine expression on the surface of immune cells in the tumour microenvironment and found targeted radiation treatment increases PS expression on immune cells when inflammation was highest in the microenvironment.
Tumour Infiltrating Effector Memory Antigen-Specific CD8+ T‑Cells Predict Response to Immune Checkpoint Therapy
An oncology study to determine if infiltrating T-cells could be used as a biomarker for response to immune checkpoint inhibitor therapies.