SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
A recent study has used single-cell RNA-seq data to analyse human, non-human primate and mouse barrier tissue to identify putative SARS-CoV-2 targets.
Memory of EpSC in Wound Healing
Summary of a study investigating how skin inflammation effects EpSCs to allow them to speed up barrier restoration following subsequent tissue damage.
Platelets are major suppressors of T cell function
We currently offer validated models to address immune function in tumour bearing mice. Our detailed flow cytometric expertise can further assess the identity of tumour infiltrating and peripheral cell populations such as CD8+ T cells, MDCSs and regulatory T cells, by surface identification of key molecules, or the intracellular mediators they express (cytokines, transcription factors).
On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier
We currently offer in vivo models of rheumatoid arthritis, psoriasis and inflammatory bowel disease.