Choosing the best preclincal oral mucositis model to demonstrate efficacy or Mechanism of Action

The oral mucosa is a stratified squamous epithelium that has a crucial barrier function. Any damage or loss of integrity during oncology therapies poses a major risk of infection, since such patients are often also immunocompromized. Furthermore, the large ulcerations can be so painful that patients are often unable to eat and require hospitalization and enteral nutrition.

Citrulline as a Biomarker of GI Toxicity

Citrulline is produced by small bowel enterocytes, with circulating citrulline levels correlating with enterocyte mass. Changes in enterocyte number (or in some cases function) are therefore reflected in plasma levels. As a result, citrulline levels may be a biomarker for various GI syndromes