Triggering of a Dll4–Notch1 loop impairs wound healing in diabetes
Diabetic foot ulceration (DFU), a chronic diabetes complication, represents a major medical, social and economic problem. This study identified a Notch1 signaling pathway as a crucial mediator of impaired wound healing in diabetes.
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Mammalian adult skin wounds typically heal by fibrotic repair without hair follicle (HF) regeneration. This study is the first to show that de novo HFs can be regenerated in adult skin by modulating a Shh pathway in the dermis.
Improved healing of large wounds via the reprogramming of wound-resident mesenchymal cells into epithelial cells
The authors of this paper demonstrated that mesenchymal cells within a large wound could be converted into keratinocytes in vivo via the transduction of four genes. This improved re-epithelialization of wounds through generation of new epithelial tissue that showed normal morphology/characteristics and eventually connected to host skin. The paper provides proof of principle for a new wound healing treatment particularly useful for large wounds that normally require skin grafts.
Memory of EpSC in Wound Healing
Summary of a study investigating how skin inflammation effects EpSCs to allow them to speed up barrier restoration following subsequent tissue damage.
A new opportunity to reduce scarring by converting myofibroblasts to adipose cells?
Epistem has validated in vivo excisional and incisional, human skin engraft, diabetic and LPS-induced inflammation wound healing models. In vitro wound healing assays are also available to assess cell proliferation/migration, wound closure and angiogenesis.
FDA approval for new diabetic wound dressing.
Epistem validated in vivo diabetic wound healing model showing delayed wound healing (wound closure and re-epithelisation) and a decreased inflammatory response.